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KMID : 1059520100540050506
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Journal of the Korean Chemical Society
2010 Volume.54 No. 5 p.506 ~ p.514
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Synthesis, Characterization and Biological Activity of Some Complexes of Some New Amino Acid Derivatives N-[(Benzoyl amino)-Thioxomethyl]-Amino Acid(HL)
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Al-Mudhaffar, Dhafir M.H.
Al-Edani, Dawood S.
Dawood, Suma M.
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Abstract
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A new series of ligands N-[(benzoylamino)-thioxomethyl]-amino acid (HL) were synthesized by reaction of benzoylisothiocyanate with various amino acids namely aspartic acid [BATA] (1), glutamic acid [BATG] (2), methionine [BATM] (3), leucine [BATL] (4), and tryptophan [BATT] (5). The ligands were characterized by elemental analysis, IR and NMR spectra. Some transition metal complexes (ML₂) for these ligands (6-8) were prepared; [M=Cu(II), Co(II), or Ni(II)], and characterized by elemental analysis, IR and ¹H NMR spectra. Antibacterial study showed that all the ligands have no antibacterial activity, whereas (ML₂) complexes; [M = Cu(II), Co(II), or Ni(II)] have antibacterial activity towards (Gram -ive) Escherichia (NCTC5933) and (Gram +ive) Staphylococcus (NCTC6571) and have no toxicity on (BALB/C) Albino mice.
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KEYWORD
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Ligands, Amino acid, Benzoylisothiocyanate, Transition metals, Antibacterial activity
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